Eli Lilly and Merida Biosciences, have announced a definitive agreement for Lilly to acquire Merida.
Merida is developing biologics engineered to selectively degrade pathogenic autoantibodies, the disease-causing agents behind a range of immune-mediated conditions. The precision degradation approach is intended to address the biological cause of these diseases, rather than broadly suppressing the immune system, as many current therapies do.
Merida’s lead programme, MER511, is in phase 1 development for Graves’ disease and thyroid eye disease (TED), conditions driven by thyroid-stimulating immunoglobulins, which are autoantibodies that activate the thyroid-stimulating hormone receptor. Graves’ disease affects approximately three million people in the US, and patients face elevated cardiovascular risk and mortality.
Roughly 25% to 40% of people with Graves’ disease go on to develop TED, which can cause pain, disfigurement, and in severe cases, vision loss. While there are approved treatments for both conditions, none directly target the autoantibodies that cause them. Because pathogenic autoantibodies drive a wide range of serious diseases, Merida’s platform has potential application well beyond its lead programme.
The company’s pipeline also includes MER769, a preclinical programme focused on food allergy, asthma, chronic spontaneous urticaria and other diseases driven by the antibody responsible for triggering allergic reactions, along with earlier-stage programs in kidney diseases such as membranous nephropathy and other immune-mediated conditions.
